Hydroalkylation of Styrenes with Benzylamines by Potassium Hydride
نویسندگان
چکیده
A method for the synthesis of 1,3-diarylpropylamines through hydroalkylation styrenes with benzylamines by potassium hydride has been developed. The protocol is initiated solvothermal treatment KH at 100 °C to generate deprotonated anionic species, which undergo selective C-alkylation arylalkenes 0 ambient temperature afford as major product.
منابع مشابه
Enantioselective Synthesis of Carbo- and Heterocycles through a CuH-Catalyzed Hydroalkylation Approach
The enantioselective, intramolecular hydroalkylation of halide-tethered styrenes has been achieved through a copper hydride-catalyzed process. This approach allowed for the synthesis of enantioenriched cyclobutanes, cyclopentanes, indanes, and six-membered N- and O-heterocycles. This protocol was applied to the synthesis of the commercial serotonin reuptake inhibitor (-)-paroxetine.
متن کاملInverse potassium hydride: a theoretical study.
Results of an experimental study on the unusual "inverse" charge state (H(+)Na(-)) in salts where the H(+) ion is sequestered, combined with our earlier theoretical calculations on an unsequestered model compound (Me(3)N-H(+)...Na(-)), prompted us to further investigate such systems. In particular, we examined Et(3)N-H(+)...K(-) because considerations of the proton affinity of the amine and of ...
متن کاملMinimum Heat of Formation of Potassium Iodo Hydride
] that a novel inorganic hydride compound KHI which comprised a high binding energy hydride ion was synthesized by reaction of atomic hydrogen with potassium metal and potassium iodide. Potassium iodo hydride was identified by time of flight secondary ion mass spectroscopy, X-ray photoelectron spectroscopy, 1 H and 39 K nuclear magnetic resonance spectroscopy, Fourier transform infrared spectro...
متن کاملPorphycene-mediated photooxidation of benzylamines by visible light.
A variety of primary and secondary benzylic amines were oxidized efficiently to N-benzylidenebenzylamines and imines, respectively, using 2,7,12,17-tetrapropylporphycene (H(2)TPrPc) photocatalyst and blue light emitting diodes (LEDs). The photooxidation of 4-methoxybenzylamine in the presence of H(2)TPrPc and its tin(IV) complex Sn(TPrPc)Cl(2) was studied in detail in order to show that operati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Helvetica Chimica Acta
سال: 2021
ISSN: ['1522-2675', '0018-019X']
DOI: https://doi.org/10.1002/hlca.202100120